Author(s):

Semwal Amit*, Farswan Mamta Singh

Abstract: Parasitic diseases cause severe morbidity by affecting population in endemic areas with major economic and social consequences. More than half of the population of the world suffers from various types of infection and majority of cattles suffer from worm infections. So there is a need to find new drugs to treat parasitic diseases. Ethanolic, aqueous and petroleum ether extract from the rhizome of Diplaziumesculentum (Retz.) Sw (Family- Athyriaceae) was investigated for their anthelmintic activity against Pheretima posthuma. Three concentrations (10, 25 and 50 mg/ml) of each extracts were studied, which involved the determination of time of paralysis and time of death of the worm.It was found that all the extracts exhibited significant anthelmintic activity. Piperazine citrate in same concentration as that of extract was included as standardreference and distilled water as control. Results showed that the ethanolic extract was more potent as compared to other extracts as it took less time to cause paralysis and death of the earthworms as compared to standard reference drug.

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