Author(s):

AVS. Praveen Kumar*, Venu Gopal Jonnalagadda, Jyothi M Joy, Prathyusha. S, Mohana Lakshmi

Abstract: Objective: From the past few years there is increasing research interest on the natural compounds, due to their wide variety of pharmacological activities. The main aim of the present study was to conduct the evaluation of the Poly herbal suspension (PHS) which includes the preliminary phytochemical screening, standardisation and experimental antiulcer activity. Methods: In this study we conduct the phytochemical screening, standardisation using the high performance thin layer chromatography (HPTLC) & infra-red spectroscopy (IR). Also, the PHS was evaluated for the acute toxicity and antiulcer activity at 400 mg/kg and 800 mg/kg in adult albino wistar rats induced by the ethanol (1ml/kg), indomethacin (40mg/kg) and aspirin (150mg/kg) ulcer models. Results: After phytochemical screening, the PHS showed the presence of the terpenoids, flavonoids and tannins which produces antiulcer activity. The therapeutic efficacy achieved at both dose levels of the PHS when compared with the standard sucralfate (100mg/kg) showed a significant (P<0.05) antiulcer activity in ethanol induced model, PHS shown a significant reduction (P<0.05) of ulceration when compared with the indomethacin induced control group as that of misoprostol (100 mcg/kg) and same as the above it shown the anti-ulcerogenic protection in aspirin induced model, here the standard drug was omeprazole (10mg/kg). The highly significant antiulcer activity was exhibited at dose level of 800mg/kg. Conclusion: The results of the present study showed the pronounced anti-ulcerogenic activity of the PHS at the dose of 800mg/kg after the standard phytochemical and pharmacognostical study

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