Author(s):

LM. C. Cordeiro¹, B. B. Kaliwal¹

Abstract: The present investigation was undertaken to evaluate the protective role of bark extracts of Bridelia retusa S. on the liver and kidney after CCl4 intoxication. The bark of Bridelia retusa S. was powdered and subjected to sequential extraction based on polarity using solvents such as petroleum ether, chloroform, ethanol and distilled water. The extract was filtered, concentrated, dried and stored in refrigerator until further use. Oral suspensions containing 25 and 50 mg/kg body weight of ethanolic and aqueous extracts were administered for 5 days to carbon tetrachloride treated female mice. The protective role of ethanolic and aqueous stem bark extracts of Bridelia retusa S. were investigated on histological profiles of liver and kidney. The effect of 50 mg of ethanolic extract was visible by reduced CCL4 induced toxicity on the histology of liver and kidney which were restored to that of normal better than aqueous extract wherein steatosis and dilation of central vein caused by CCl4 was reduced and normalized hepatocytes. Hence, the present study indicates that both the extracts possessed amelioration of histological changes in the liver and kidney of CCl4 intoxicated mice though ethanolic extract showed better recovery in dose dependent manner.

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