Author(s):

Dilnawaz Pathan, Shirishkumar Ambavade

Abstract: Purpose: The aim of the study was to investigate anticonvulsant effect of alcoholic extract of roots of Vanda roxburghii on electrically and chemically induced seizures. Methods: The ethanolic extract of the roots of Vanda roxburghii (SVR) was studied for its anticonvulsant effect on maximal electroshock-induced seizures pentylenetetrazole, picrotoxin induced seizures in mice. The latency of tonic convulsions and the number of animals protected from tonic convulsions were observed. Results: It has been observed in the present study that the ethanolic extract of roots of Vanda roxburghii (100 mg/kg) showed significant (P<0.05) increase in latency to clonic convulsions. Vanda roxburghii possess anticonvulsant activity against Pentylenetetrazole (PTZ), Maximal electroshock (M.E.S.) and Picrotoxin (PTX) induced convulsions in mice.

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