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Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 3, Issue 1 (2014)

Cytotoxic triterpenes from Diospyros kaki L. cv. costata (Ebenaceae)

Author(s): Ola A. Sanad, Azza R. Abdel Monem, Zeinab A. Kandil
Abstract: Four flavonoids (kaempferol-3-O-β-D-glucoside, quercetin-3-O-β-D-glucoside, kaempferol, and quercetin) and three triterpenes (ursolic acid, 3,19,24-trihydroxyurs-12-en and 3,19,24-trihydroxy-15-oxo-urs-12-en) were isolated from the ethyl acetate fraction of the alcoholic extract of Diospyros kaki L. cv. costata leaves cultivated in Egypt. The cytotoxic activity of 3,19,24-trihydroxyurs-12-en and 3,19,24-trihydroxy-15-oxo-urs-12-en was assessed on three human cell lines, cervical carcinoma (HELA), breast carcinoma (MCF7) and colon carcinoma (HCT116) cell lines using sulforhodamine-B assay. The two compounds exerted a moderate cytotoxic activity against the three tested cell lines comparing to doxorubicin as reference standard.
Structure of compounds 2 and 3 2:      R         H  3:       R       =O
Fig.: Structure of compounds 2 and 3 2: R H 3: R =O
Pages: 231-234  |  1040 Views  13 Downloads
How to cite this article:
Ola A. Sanad, Azza R. Abdel Monem, Zeinab A. Kandil. Cytotoxic triterpenes from Diospyros kaki L. cv. costata (Ebenaceae). Journal of Pharmacognosy and Phytochemistry. 2014; 3(1): 231-234.
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