Author(s):

N.Shanthi, T.Eluvakkal and K.Arunkumar

Abstract: Fucoidan is a group sulfated hetero polysaccharide found in the cell wall of some members of Phaeophyceae. Two fractions of fucoidan one with low molecular weight (LMW) with> 3500 Da and another with high molecular weight (HMW) with <3500 Da showed promising anticoagulation activity under in vitro APTT assay were isolated from the brown seaweed Turbinaria decurrens occurring along the coast of Pamban (Gulf of Mannar), India. Fucoidan isolated using DEAE Cellulose column was characterized by FTIR spectroscopy dominating galactose followed by fucose, mannose and glucose. But more anticoagulation activity was recorded in HMW A1H fraction than LMW fraction isolated from the brown seaweed Turbinaria decurrens. The anticoagulation activity was an increased with increase in the sulphate content in the fucoidan.

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