Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 3, Issue 3 (2014)

Cytotoxic and genotoxic activities of the crude ethanolic leaf extract of Ficus odorata (Blco). Merr. against human hepatocellular carcinoma

Author(s): Librado A. Santiago, Kelsey C. Dayrit, Pamela Cjisel B. Correa, Angel Camille M. Aguila, Mary Rosary M. De Leon, and Anna Beatriz R. Mayor
Abstract: Due to the prevalence of liver cancer in the Philippines, the study focused on the use of endemic medicinal plant, Ficus odorata, as a possible chemopreventive agent. In this study, it was demonstrated that the crude ethanolic leaf extract of F. odorata has a potent cytotoxicity towards HepG2 cells and was further supported by its genotoxic activity as assessed by both Comet and TUNEL assays. The crude extract was also able to induce the release of caspase 3 protease that activates cell apoptosis. Considering these, F. odorata is a potential anticancer agent.
Pages: 33-38  |  1091 Views  16 Downloads
How to cite this article:
Librado A. Santiago, Kelsey C. Dayrit, Pamela Cjisel B. Correa, Angel Camille M. Aguila, Mary Rosary M. De Leon, and Anna Beatriz R. Mayor. Cytotoxic and genotoxic activities of the crude ethanolic leaf extract of Ficus odorata (Blco). Merr. against human hepatocellular carcinoma. 2014; 3(3): 33-38.
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