Author(s):

Mamdouh N. Samy, Hany E. Khalil, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka, Mohamed S. Kamel

Abstract: The present study was carried out to evaluate various biological effects of the phytochemical constituents as well as extracts of Ruellia patula Jacq. and Ruellia tuberosa Linn. The study revealed that Rp-MeOH, Rp-Hexane, Rt-MeOH, Rt-Hexane and Rt-13 exhibited marked cytotoxic activity while, the compounds Rp-15, Rp-7, Rt-4 and Rt-12 exhibited moderate cytotoxic activity when compared with the positive control, doxorubicin. The compound Rt-13 showed a noticeable free radical scavenger activity, while Rp-EtOAc, Rp-7, Rp-15 and Rt-4 exhibited a moderate activity when compared to the reference compound, trolox. The compounds Rt-8, Rt-9 and Rp-14 showed approximately half the radical scavenger activity of the reference compound. The rest of the tested compounds did not exhibit any free radical scavenger activity. Rt-Hexane showed a weak antileishmanial activity while the remaining tested extracts and compounds showed no activity. All the tested extracts and compounds were found to exhibit no antibacterial activity.

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