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Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 4, Issue 2 (2015)

Formulation and phytochemicals characterization of polyherbal (Tinospora cordifolia, Gymnema sylvestre, Pterocarpus marsupium and Acacia arabica) antidiabetic compressed tablet lozenges

Author(s): Suman Yadav, Pratibha Nand, Rajinder K. Gupta
Abstract: The goal of the study was to supply slow release medicament for the treatment of diabetes by formulating polyherbal antidiabetic compressed tablet lozenges. There is still a demand for new dosage forms that act effectively despite various other forms of dosages such as powder, tablets and injectable being available in the market. So the lozenges are the new and innovative way for drug delivery to provide a synergistic effect. Increased retention time of dosage form in the oral cavity is the major advantage of the medicated lozenges. This leads to an increased bioavailability and reduction in gastric irritation and bypass metabolism. The lozenges were prepared by a wet granulation method using Tinospora cordifolia, Gymnema sylvestre, Pterocarpus marsupium and Acacia arabica herbal extractsand other excipients like sorbitol, mannitol, PEG 6000 with lemon flavour and menthol. PVP was used as a binder, while Stevia powder was used as a sweetener. These herbs are widely used as sources of bioactive compounds like phytochemicals, antioxidants as well as for their antidiabetic effects. The formulated lozenge was subjected to various physicochemical parameters like hardness, thickness, and friability and disintegration time. The hardness of lozenges was found to be 20.3 Kg/cm². Friability was 0.59%. Thickness of lozenges was found to be 5.0 mm and disintegration time was 17 minutes. Upon carrying out of a stability study at 30 ºC & 40 °C for a period of one month, it was observed that there is no change in physico-chemical properties. The compressed tablet lozenges can provide an effective substitute for the treatment of diabetes. HPLC was carried out to identify bioactive compounds like quercetin (0.5062%), kaempferol (0.0864%), epicatechin (0.0191%) and rutin (1.2726%) which are known for their antidiabetic and antioxidant effect. The presence of Phytol, 1H-Indene, 1-ethylideneoctahydro-7 a-methyl-, (1E,3a.alpha.,7a.beta.), 2H-1-Benzopyran,6,7-dimethoxy-2,2-dimethyl, Inositol,1-deoxy, 2-Methoxy-4-vinylphenol, 2-methoxy-3-2-propenylphenol-, 2-Ethylacridine, delta-selinene and fatty acids were identified by the GC-MS analysis of various hydro alcoholic herbal extracts. All of these have significant therapeutic implications.
Pages: 244-253  |  1195 Views  29 Downloads
How to cite this article:
Suman Yadav, Pratibha Nand, Rajinder K. Gupta. Formulation and phytochemicals characterization of polyherbal (Tinospora cordifolia, Gymnema sylvestre, Pterocarpus marsupium and Acacia arabica) antidiabetic compressed tablet lozenges. Journal of Pharmacognosy and Phytochemistry. 2015; 4(2): 244-253.
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