Author(s):

Md. Ali Asif Noor, Md. Zamiul Islam, Md. Sarwar Hosain, Md. Shahid Sarwar, Md. Mosiqur Rahman, Mamunur Rashid, Mohammad Safiqul Islam, Md. Asaduzzaman

Abstract: Xanthosoma sagittifolium is widely used in the folkloric treatment system of Bangladesh for the treatment of different diseases. The present study was conducted to evaluate the analgesic and anti-inflammatory potentiality of methanol extract of Xanthosoma sagittifolium in mice. Analgesic activity was evaluated by tail emersion and acetic acid induced writhing method whereas anti-inflammatory activity was investigated by Carrageenan induced mice paw edema method. Our study explored that the analgesic activity followed upward for Diclofenac-Na during the observation within 120 minutes and fall down within 180 minutes range. Likely, the methanolic plant extract at different concentrations showed upward movement and fallen down when it reached at 180 minutes. Comparing to standard drug, the plant extract at 200 mg/kg body weight concentration performed better analgesic activity. The tail emersion method showed that the highest analgesic activity (8.25  0.96) was found after 120 minutes at 200 µg/ml extract. On the other hand, the acetic acid induced writhing method explored that plant extract at a dose of 200 µg/ml produce significant pain inhibition (84.48%). Carrageenan induced mice paw edema method showed that highest % of inhibition (74.77%) was found at a dose of 200µg/ml extract after 120 minutes of time period. Our results show that X. Sagittifolium has considerable analgesic and antioxidant activity. So, further research can be performed here to find out the responsible active compounds and to identify the mechanism of actions.

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