Material and Methods: Diabetes was induced by a single intraperitoneal injection of alloxan (120 mg/Kg). Rats were divided into four groups. Group I (standard control): treated orally with the reference drug, Glibenclamide. Group II (diabetic Control): diabetic rats untreated. Group III and IV: diabetic rats treated with methanol and aqueousrnleaf extract of M. scabrum (300 mg/kg). After the last treatment, blood samples were collected for estimation of serum glucose, liver enzymes, triacylglycerol, total cholesterol, HDL, LDL and VLDL. 

Results: Methanol and aqueous leaves extracts significantly decreased (P < 0.05) fasting blood glucose in alloxan-induced diabetic rats from 10.10 ± 4.815 to 5.80±1.608 mmol/l and 18.85±8.33 mmol/l to 12.525±7.463 mmol/l respectively. The extracts also caused a significant (P < 0.05) decrease in serum triglyceride, total cholesterol, LDL-cholesterol and increase in HDL-cholesterol. 

Conclusion: This results revealed that M. scabrum is effective in the management of diabetes mellitus.