Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 5, Issue 1 (2016)

Effect of Plumeria alba Linn. (Apocynaceae) fractions on some parameters of high fat diet induced metabolic syndrome in mice

Author(s): Kadebe ZT, Bakoma B, Lawson-Evi P, Metowogo K, Eklu-Gadegbeku K, Aklikokou K, Gbeassor M
Abstract: The root of P. alba is traditionally used to treat type 2 diabetes. The aim of this study was to evaluate the preventive effect of P. alba fractions on some markers of metabolic syndrome induced by lard- fructose diet in ICR mice. The mice were fed with lard - fructose mixture for 28 days, from the 15th to 28th day, 30 minutes before mice were given distilled water (Hyperlipidemic control), metformin (100 mg/kg), Ethyl Acetate fraction or Supernatant fraction (100 mg/kg per day) for the treatment. After 28 days of the experiment, fasting blood glucose, body weight gain, intra-abdominal fat, serum triglycerides (TG) and total cholesterol levels in the treated groups were significantly (p<0.01) lower than that of Hyperlipidemic control group. In the glucose tolerance test, treated group showed a significant (p<0.01) reduction of blood glucose during 180 minutes after glucose loading, which indicates that the fractions of P. alba improve glucose tolerance. The finding in this study reveals that P. alba fractions can prevent metabolic syndrome induced by lard-fructose diet in mice.
Pages: 211-215  |  1069 Views  23 Downloads
How to cite this article:
Kadebe ZT, Bakoma B, Lawson-Evi P, Metowogo K, Eklu-Gadegbeku K, Aklikokou K, Gbeassor M. Effect of Plumeria alba Linn. (Apocynaceae) fractions on some parameters of high fat diet induced metabolic syndrome in mice. Journal of Pharmacognosy and Phytochemistry. 2016; 5(1): 211-215.
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