Author(s):

Sanjana Datta, Ram Nath Mishra, Prashant Kumar, Kamal Dua

Abstract: The present study was designed to evaluate the adaptogenic activity of hydroethanolic extract of roots of Plumbago zeylanica and Plumbago rosea on Swiss Albino mice using swimming endurance test. The Plumbago zeylanica (Linn.) and Plumbago rosea (Linn.) extract were found to be safe 2000 mg/kg of body weight. Therefore 1/5 and 1/10^th cut off dose for Plumbago zeylanica (Linn.) and Plumbago rosea (Linn.) extract are 100 and 200 mg/kg were selected for present study (OECD 2000). The swimming time of mice was 289.7 s (S-100), 363.0 s(S-200) and 312.8 s (S-100), 396.7 s (S-200) for Plumbago zeylanica extract S and Plumbago roseaextract a respectively and the same was 224.3 s and 478.0 s for control and standard (Korean Ginseng).

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