Author(s):

Kadebe ZT, Bakoma B, Lawson-Evi P, Metowogo K, Eklu-Gadegbeku K, Aklikokou K, Gbeassor M

Abstract: The root of P. alba is traditionally used to treat type 2 diabetes. The aim of this study was to evaluate the preventive effect of P. alba fractions on some markers of metabolic syndrome induced by lard- fructose diet in ICR mice. The mice were fed with lard - fructose mixture for 28 days, from the 15^th to 28^th day, 30 minutes before mice were given distilled water (Hyperlipidemic control), metformin (100 mg/kg), Ethyl Acetate fraction or Supernatant fraction (100 mg/kg per day) for the treatment. After 28 days of the experiment, fasting blood glucose, body weight gain, intra-abdominal fat, serum triglycerides (TG) and total cholesterol levels in the treated groups were significantly (p<0.01) lower than that of Hyperlipidemic control group. In the glucose tolerance test, treated group showed a significant (p<0.01) reduction of blood glucose during 180 minutes after glucose loading, which indicates that the fractions of P. alba improve glucose tolerance. The finding in this study reveals that P. alba fractions can prevent metabolic syndrome induced by lard-fructose diet in mice.

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