Vol. 5, Issue 3 (2016)
Ameliorative effect of Bacopa monnieri on alcohol induced hepatotoxicity and oxidative stress in albino rats
Author(s): D Veera Nagendra Kumar, K Lakshmi Narasaiah and S Prakash Rao
Abstract: Alcoholic liver disease is one of the most serious consequences of chronic alcohol abuse and the oxidative stress plays an important role in the development of the disease. The current investigation has been conducted to investigate the influence of Bacopa monnieri on hepatic antioxidant status in alcohol treated rats. Administration of alcohol (2g/kg/day) for 6 weeks resulted in liver injury and tested animals were treated orally with plant extract (200mg/kg), prior to ethanol administration. Hepatic marker enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT) alkaline phosphatase (ALP) were analysed in serum. Hepatic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) activities and reduced glutathione (GSH) content and malondialdehyde (MDA) level were studied. The extract produced significant (p<0.001) decreases AST, ALT, ALP activities, malondialdehyde levels and also increases liver antioxidant enzymes in alcohol treated rats. However, Bacopa monnieri extract supplementation to the alcohol treated rats reversed these effects and attained the antioxidant status to normal levels. The present study suggest that aqueous extract of Bacopa monnieri offers protection against oxidative stress and its ability might be attributed to its antioxidant potential.
How to cite this article:
D Veera Nagendra Kumar, K Lakshmi Narasaiah and S Prakash Rao. Ameliorative effect of Bacopa monnieri on alcohol induced hepatotoxicity and oxidative stress in albino rats. Journal of Pharmacognosy and Phytochemistry. 2016; 5(3): 287-292.