Author(s):

Sumana Khandaker, Sajan Das, FAD Md. Opo, Rumana Akhter and Mohammad Shahriar

Abstract: The present study was done to evaluate in vivo anti-pyretic, gastrointestinal motility, anti-nociceptive, neuropharmacological and acute toxicity effects of different leaf extracts of Calamus viminalis in Swiss albino mice following oral administration. In vivo gastrointestinal motility test revealed that both the doses of ethanol extracts (100 and 200 mg/kg body weight) and the dose of 200 mg/kg body weight of methanol extract showed maximum charcoal defection time, compared with the effect produced by standard drug. Both methanol 100 and 200 mg/kg and chloroform 200 mg/kg extracts showed significant in vivo anti-pyretic effect on mice. Statistically significant (p<0.01, p<0.001) results were found in case of in vivo anti-nociceptive activity test for the 100 and 200 mg/kg methanol extracts when compared to standard diclofenac-Na. In case of neuropharmacological activity, ethanol extract 200 mg/kg body weight showed statistically significant (p<0.001) result with highest time of immobility of 191.5 second. None of the extracts showed any significant in vivo acute toxicity effect on mice.

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