Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 5, Issue 6 (2016)

Bioactivity-guided isolation of two sesquiterpenes with potential anti-fungal activity from Citrullus colocynthis L. (Schard)

Author(s): Soud AAA Jeeb, Mona S Mohammed, Fathelrahman AE, Wadah J Osman and Hassan S Khalid
Abstract: Fungal infection is one of the most frequent and widely distributed skin diseases of human, pets and livestock. Different pharmacological treatments have been recommended, but recently the use of some natural plant products has been emerged since they are safer to human than the chemical antifungal compounds.
Phytochemical investigation of aerial parts of C. colocynthis resulted in isolation of two new sesquiterpineMS-6 (Germacr-3-ol-8-en-6,12-oxy-15-oic acid) and MS-2 (5,6-[4,butyl-1,3-dioxino]-7-ene-oxecine) along with several known compounds. The two compounds have shown potent anti-fungal activity evaluated by using of Cup-Plate agar diffusion method. These compounds may provide a chemical moiety for more potent analogues.
Pages: 422-425  |  884 Views  34 Downloads
How to cite this article:
Soud AAA Jeeb, Mona S Mohammed, Fathelrahman AE, Wadah J Osman and Hassan S Khalid. Bioactivity-guided isolation of two sesquiterpenes with potential anti-fungal activity from Citrullus colocynthis L. (Schard). Journal of Pharmacognosy and Phytochemistry. 2016; 5(6): 422-425.
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