Author(s):

Mohamed S Hifnawy, Hanaa A Kassem, Hanaa H Eid, Tohamy AF, Moataz B El Naggar, Dalia O Saleh and Inas Y Younis

Abstract: The present study was conducted to evaluate the hypolipidemic activity of Egyptian Tropaeolum majus L. leaves on lipid parameters (total cholesterol, triglycerides, low density lipoproteins, high density lipoproteins, atherogenic index and cardiac risk ratio) of hyperlipidemic rats as well as its effect on vital body organs (aorta, heart and liver). In addition to, the histopathological examinations and x-vivo relaxant test of the hyperlipidemic aortic strip. LC /MS/MS analysis was carried out to screen the biologically active compounds that may contribute to the activity. Results showed that all lipid parameters were significantly reduced after administration of the hydroalcoholic extract of Tropaeolum majus for 5 consecutive weeks, and the histopathological pictures were improved. While, LC /MS/MS analysis revealed that flavonoids contribute the highest percentage (91.9%) of the relative area of the hydroalcoholic extract of Tropaeolum majus L. leaves. Isoquercetrin was the main flavonoids (67%), in addition to isorhamntein3-o- glycoside and quinic acid derivatives. Tropaeolum majus L. could be used as a new promising plant against the progress of cardiovascular diseases.

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