Author(s):

Nafessa Saeed Khalaf Allah, Ikram Mohamed Eltayeb and Amna El Hassan Hamad

Abstract:
Vigna unguiculata belonging to the family Fabaceae is widely grown in Africa. In Sudan there are a number of varieties which are commonly as food. The plant is traditionally used for treating of many diseases such as stomatitis, corneal ulcers, colic diseases, epilepsy, chest pain and sexually transmitted diseases. This study represents the first attempt to investigate the lipid profile effect of V. unguiculata leaf and seed extracts. Thirty-five Wistar rats divided into seven groups were used in the experimental study. Five rats in each group as follows; normal control group fed on normal diet and hypercholesterolemic groups fed with high cholesterol diet. The hypercholesterolemic groups were further divided into six groups with five rats in each group. The first group (control group), received hypercholesterolemic diet only; second group treated with Atorvastatin, standard drug (0.18 mg/Kg). Third and fourth group received ethanolic extract of V. unguiculata seeds of 250 mg/Kg and 500 mg/Kg respectively. Fifth and sixth groups received ethanolic extract of V.uiculata leaves 250 mg/Kg and 500 mg/Kg respectively. Blood samples were taken from the Retro-orbital venous plexus after four weeks of the experiment from all group after 24 hours fasting. The lipid profile parameters, TC, TGs, LDL, HDL, were measured. The results revealed that, seed extract posses the more hypolipidemic activity than leaf extracts through the reduction of total cholesterol (TC) and low density lipoprotein (LDL).

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