Objectives: The present research work was designed to investigate the effects of different fractions of Phosphatidylcholine (PC), its antioxidant property in streptozotocin induced Alzheimer’s disease in mice.

Methods: Intracerebroventricular administration of Streptozotocin to induce cognitive dysfunction & oxidative stress as an Alzheimer’s disease in Swiss albino mice. Morris water maze, Elevated plus Maze were used to study cognitive behavior.

Results: Treatment of ICV STZ produced a significant decrease in MWM and EPM performance of mice hence reflecting loss of learning and memory. The study of the memory in Alzheimer’s disease was found that PC 95 and 55 (200 and 300mg/kg) treated STZ-injected mice showed significant results. The time spent with target quadrant in MWM and retention latency in EPM was increases with PC as compared to STZ group.

Conclusion: Phosphatidylcholine showed improvement in cognitive impairment & it is a good promising candidate for increasing memory in Alzheimer’s disease. The study demonstrates the effectiveness of PC in preventing the cognitive deficits as well as the oxidative stress caused by ICV STZ in mice and suggests its potential in age neurodegenerative disorders. In STZ induced memory deficit, there is a decreased activity of glycolytic enzymes resulting in a reduction in acetylcholine level which is intricately associated with cognition. PC showed memory improvement by its potent antioxidant action, is enhancement in CBF and energy metabolism.