Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 6, Issue 5 (2017)

Chloroform Extracts of Ipomoea alba and Ipomoea tricolor Seeds Show Strong In-vitro Antibacterial, Antifungal, and Cytotoxic Activity

Author(s): Sims K Lawson, Mary N Davis, Carolyn Brazell, William N Setzer
Abstract:
Extracts from the seeds of two morning glories were studied to determine their anti-microbial activity. Ipomoea alba and Ipomoea tricolor were analyzed by broth microdilution technique. I. alba extract showed very strong antibacterial activity against Enterococcus faecalis and Bacillus cereus, with minimum inhibitory concentration (MIC) values of 19.5 µg/mL for both. Antifungal activity was also observed against Cryptococcus neoformans, with MIC of 78 µg/mL. Strong cytotoxicity against the human breast cancer cell line MDA-MB-231, with IC50 value of 35.72 ± 1.86 µg/mL was observed. I. tricolor extract showed strong activity against E. faecalis and B. cereus, with MIC values of 19.5 and 9.75 µg/mL, respectively. Strong activity was observed against Cryptococcus neoformans, with MIC of 9.75 µg/mL. Strong cytotoxicity was also observed against human breast cancer cell lines MDA-MB-231 and Hs 578T, with IC50 values of 28.47 ±1.98 µg/mL and <30 µg/mL, respectively.
Pages: 730-734  |  538 Views  33 Downloads
How to cite this article:
Sims K Lawson, Mary N Davis, Carolyn Brazell, William N Setzer. Chloroform Extracts of Ipomoea alba and Ipomoea tricolor Seeds Show Strong In-vitro Antibacterial, Antifungal, and Cytotoxic Activity. Journal of Pharmacognosy and Phytochemistry. 2017; 6(5): 730-734.
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