Vol. 6, Issue 5 (2017)
Membrane stabilizing and thrombolytic activities of methanolic extract of Trichosanthes dioica Roxb. Shoot
Author(s): Rumana Yesmin, Polash Chandra Karmakar, Hanif Ali and Kamal Krishna Biswas
Pointed gourd (Trichosanthes dioica) is a common and popular vegetable in our country. This vegetable is locally known as “Patal’’. The shoot of pointed gourd (Pataler loti) is also used as a vegetable. The present study was undertaken to evaluate the inherent anti-inflammatory and thrombolytic activity of methanolic extract of the shoots of Trichosanthes dioica (METDS). In vitro anti-inflammatory activity was uncovered by using human erythrocyte membrane stabilization and egg albumin denaturation method. In vitro thrombolytic activity was investigated and compared with streptokinase. In hypotonic solution-induced haemolysis and heat-induced haemolysis, METDS protects 66.39%, 71.59% RBC from lysis. METDS dose dependently showed a potent anti-inflammatory and anti-arthritic activity. In addition, thrombolytic activity was found to be 28.46±4.16%, 9.67±6.37 and 65.96±4.25% for METDS, normal saline and streptokinase (a positive control) respectively. Therefore, it can be concluded that the shoots of Trichosanthes dioica possess promising thrombolytic, anti-inflammatory that may be a potential agent for prevention of inflammation.
How to cite this article:
Rumana Yesmin, Polash Chandra Karmakar, Hanif Ali and Kamal Krishna Biswas. Membrane stabilizing and thrombolytic activities of methanolic extract of Trichosanthes dioica Roxb. Shoot. Journal of Pharmacognosy and Phytochemistry. 2017; 6(5): 2500-2502.