Vol. 6, Issue 6 (2017)
Exploration of Immunomodulatory Effect of Nilavembu Kudineer Chooranam against Newcastle Disease Virus in Backyard Chicken
Author(s): R Kavinilavan, P Mekala, MJ Raja, M Arthanari Eswaran and G Thirumalaisamy
Nilavembu Kudineer Chooranam(NKC) was subjected to preliminary phytochemical screening and its immunomodulatory activity was assessed in sixty day-old unsexed backyard chicken divided into six treatment groups of ten each. T1 served as control, T2 was vaccine control, T3 was positive control treated with levamisole, T4 - T6 were administered Nilavembu Kudineer Chooranam (NKC) @ 0.5, 1.0 and 2.0mL/kg body weight respectively for five days before vaccination. The birds (T2 - T6) were vaccinated with oral pellet vaccine (D58 strain) against Newcastle disease virus at the end of 1st, 4th and 8th week and HI titre was evaluated at the end of 4th, 8th, 12th and 16th week in all the groups. Throughout the experiment, the group pretreated with NKC @ 1.0mL/kg (T5) had shown significantly higher titre when compared to vaccine control (T2). The positive control (T3) was numerically better than vaccine control (T2) throughout the study. At the end of 12th and 16th week, the titre of positive control was significantly less than T5. The results revealed that NKC when used @ 1.0mL/kg for 5 days in drinking water before immunization resulted in improvement in immune response in backyard chicken.
How to cite this article:
R Kavinilavan, P Mekala, MJ Raja, M Arthanari Eswaran and G Thirumalaisamy. Exploration of Immunomodulatory Effect of Nilavembu Kudineer Chooranam against Newcastle Disease Virus in Backyard Chicken. Journal of Pharmacognosy and Phytochemistry. 2017; 6(6): 749-751.