Vol. 6, Issue 6 (2017)
Evaluation of antidiarrhoeal activity of polyherbal preparation
Author(s): SS Mehesare, SP Waghmare, MG Thorat, SW Hajare, PR Itankar, MFMF Siddiqui and S Sajid Ali
Antidiarrhoeal activity of polyherbal preparation containing hydro-ethanolic extracts of unripe fruits of Aegle marmelos, bark of Dalbergia sissoo and seeds of Holarrhena antidysenterica was evaluated in mice using castor oil induced diarrhea. Acute toxicity study revealed no visible signs of toxicity at 500, 1000 and 2000 mg/kg body weight in mice within and after 24 hrs. The results showed that the polyherbal preparation (400 mg/kg and 800 mg/kg) produced significant (p<0.01) reduction in frequency of defecation up to 79.56% and 81.14%, respectively as compared to control group mice in castor oil induced diarrhoea. The antidiarrhoeal action exhibited by polyherbal preparation might be due to active phytoconstituents such as alkaloids, flavonoids, tannins, sterols and saponins present in the polyherbal extracts as evident from phytochemical analysis (qualitative) carried out in the present investigation. The study concluded that polyherbal preparation containing hydro-ethanolic extracts of unripe fruits of Aegle marmelos, bark of Dalbergia sissoo and seeds of Holarrhena antidysenterica possess potent antidiarrhoeal activity.