Author(s):

R Kavinilavan, P Mekala, MJ Raja, M Arthanari Eswaran and G Thirumalaisamy

Abstract:
Nilavembu Kudineer Chooranam(NKC) was subjected to preliminary phytochemical screening and its immunomodulatory activity was assessed in sixty day-old unsexed backyard chicken divided into six treatment groups of ten each. T₁ served as control, T₂ was vaccine control, T₃ was positive control treated with levamisole, T₄ - T₆ were administered Nilavembu Kudineer Chooranam (NKC) @ 0.5, 1.0 and 2.0mL/kg body weight respectively for five days before vaccination. The birds (T_{2 -} T₆) were vaccinated with oral pellet vaccine (D58 strain) against Newcastle disease virus at the end of 1^st, 4^th and 8^th week and HI titre was evaluated at the end of 4^th, 8^th, 12^th and 16^th week in all the groups. Throughout the experiment, the group pretreated with NKC @ 1.0mL/kg (T₅) had shown significantly higher titre when compared to vaccine control (T₂). The positive control (T₃) was numerically better than vaccine control (T₂) throughout the study. At the end of 12^th and 16^th week, the titre of positive control was significantly less than T₅. The results revealed that NKC when used @ 1.0mL/kg for 5 days in drinking water before immunization resulted in improvement in immune response in backyard chicken.

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