Author(s):

Suvarna Sonwane, RS Ingole, Madhuri Hedau, PR Rathod, SW Hajare and MV Ingawale

Abstract: One hundred, day old broiler chicks were randomly divided into four equal groups. From day 0 birds from groups III and IV fed with Andrographis paniculata @ 5 gm/kg of feed. However, on day 8, each bird from group II and IV were challenged with single oral dose of E. coli broth culture @ 0.2 ml (1X 10⁹ cfu/mL). Hematological, biochemical and histopathological parameters were recorded on 14^th, 28^th and 35^th day of experiment. The significantly lower Hb, PCV and TEC were observed in group II on 14^th, 28^th and 35^th day while significant increase was observed in group IV. Differences of MCV and MCH differed significantly on 14^th day. The average mean TLC on 14^th, 28^th and 35^th days of experiment were found to be significantly increased in group II. Significantly increased absolute heterophil count and significantly decreased absolute lymphocyte count was observed in group II while group IV showed significant decrease in absolute heterophil count and increase in absolute lymphocyte count on 28^th and 35^th day. The serum total protein and albumin was significantly increased in group IV compared to group II on 14^th, 28^th and 35^th day. Serum globulin in group II differ significantly on 28^th and 35^th day among different groups. Serum AST and ALT values were significantly increased (P<0.05) in group II however, values in group IV were comparable with control group on 14^th, 28^th and 35^th day. It is thus concluded that Andrographis paniculata exhibited antibacterial effects during E. coli induced pathology in broilers.

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