Author(s):

Santhosh Anasuri, Uma Shankar Damu, Shankaraiah Pulipaka and Madhuri Tekurala

Abstract: Objective: To evaluate the leaves of the endangered traditional Indian medicinal plant Rubus moluccanus for its pharmacologically active chemical constituents and assessment of its antimicrobial and anthelmintic activities. Methods: Shade dried and pulverized leaves of the plant were macerated with different solvents to get the respective extracts that were used for chemical examination using simple test tube chemical reactions. The extract that shown to possess maximum chemical constituents was selected for Physicochemical and Pharmacological investigation. Antibacterial and antifungal activities were studied by agar disc diffusion method in comparison with standard drugs amoxicillin and ketaconazole respectively against antimicrobial sensitive and resistant, pathogenic strains of microorganisms say Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Aspergillus niger and Candida albicans. The anthelmintic activity was studied by using adult Indian earthworms Pheretima postuma using parameters like, time taken for paralysis and death of the worms and compared with standard albendazole drug. Results: The ethanolic extract of the leaves of the plant was selected for Physicochemical and Pharmacological evaluation as it was found to possess maximum chemical constituents. The crude plant extract was known to illustrate the significant antimicrobial and anthelmintic activities in comparison with reference drugs. Conclusion: More studies are recommended for isolation and chemical, pharmacological characterization of the chief chemical constituents responsible for the above discovered activities of the plant extract.

Pages: 1392-1396  |  2044 Views  540 Downloads

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