Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
Login

NAAS Rating: 5.21

updates
NAAS Rating: 5.21 new

Journal of Pharmacognosy and Phytochemistry

Vol. 7, Issue 1 (2018)

Sub-Chronic and chronic studies of effects of concurrent administration of paracetamol and aqueous extract of Hibiscus sabdariffa Linn Calyx on paracetamol hepatotoxicity in mice

Author(s): Orji Blessing O and Obi Frederick O
Abstract: This study evaluated the effects of concurrent administration of paracetamol and aqueous extract of Hibiscus sabdariffa Linn calyx on paracetamol-associated hepatotoxicity in mice under sub-chronic and chronic conditions. It comprised of four groups of five mice each to reflect control, extract only, paracetamol only and concurrent administration of paracetamol and extract. Paracetamol (500mg/kg body weight) and Hibiscus sabdariffa Linn calyx extract (250mg/kg body weight) were administered orally to experimental mice. Paracetamol toxicity was evidenced by significant increases (P≤.05) in ALT, AST, ALP and GGT activities, total cholesterol and bilirubin levels, and decreased serum total protein and albumin levels. Also found were significant decreases (P≤.05) in catalase and SOD activities, GSH level, and increase (P≤.05) in MDA level, relative to control. Concurrent administration of paracetamol and extract proved effective in ameliorating paracetamol-associated liver injury in mice particularly at the sub-chronic phase where the values of many of the parameters returned to control.
Pages: 2311-2317  |  391 Views  6 Downloads
How to cite this article:
Orji Blessing O and Obi Frederick O. Sub-Chronic and chronic studies of effects of concurrent administration of paracetamol and aqueous extract of Hibiscus sabdariffa Linn Calyx on paracetamol hepatotoxicity in mice. Journal of Pharmacognosy and Phytochemistry. 2018; 7(1): 2311-2317.
Call for book chapter
Journals List Click Here Research Journals Research Journals
Journal of Pharmacognosy and Phytochemistry