Author(s):

Anurag Singh, Ragini Srivastav and Ajai Kumar Pandey

Abstract: Background: Terminalia chebula is a potent source of useful drugs for the treatment of diabetes and its associated complications like diabetic nephropathy. This plant has numerous therapeutic properties due to which it has been proved as safe and effective drugs over hundreds of years. Objective: A large number of natural product are used by the tribal and folklore communities in many countries for the treatment of several aliments. The scope of the present study are to investigate the protective role of the seeds of Terminalia Chebula in the case STZ induced diabetic mice for Diabetic nephropathy. Materials & Methods: The dose of Terminalia chebula seed methanolic extract (TCSME) 50 mg/kg, 100 mg/kg, 200 mg/kg and 400 mg/kg per day was given daily to diabetic rats for 13 weeks. Blood glucose, serum parameters such as albumin, creatinine, total protein, lipid profile and urine parameters such as glucose, urine protein and albumin were examined. Result: TCSME significantly increases the level of serum creatinine, serum urea, and glucose. The results shows that this plant drugs are potent source of antioxidative phenolic compounds that counteract with ROS species due to which it shows protective role in the case of diabetic condition for diabetic nephropathy. After 13 weeks of treatment, in STZ-induced diabetic rats, severe hyperglycemia was developed, with marked increase in proteinuria and albuminuria. However, TCSME treatment significantly reduced proteinuria and albuminuria in diabetic rats. Conclusion: The present study reveals that the seeds of Terminalia chebula showing protective role for diabetic nephropathy and improved the oxidative enzymatic condition by minimizing the oxidative stress. Thus, It might be conclude that the seeds of Terminalia chebula used as antidiabetic agents, reduce the risk of oxidative stress and ameliorate kidney damage.

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