Author(s):

Juvatkar P, Gorde N, Khan N, Wagulde S, Naik P, Tekade B and Kale MK

Abstract: Introduction: Floating tablets prolong the gastric residence time of drugs, improve bioavailability, and facilitate local drug delivery to the stomach. With this objective, floating tablets containing aqueous extract of acacia as drug was prepared for the treatment of Helicobacter pylori and gastric ulcers. Methods: The aqueous extract of acacia was standardized by TLC. Tablets containing HPMC, Acacia extract, sodium bicarbonate (gas generating agent), talc, and magnesium stearate were prepared using direct compression method. The formulations were evaluated for physical parameters like diameter, thickness, hardness, friability, uniformity of weight, drug content, buoyancy time, dissolution, and drug release mechanism. The formulations were optimized on the basis of buoyancy time and in vitro drug release. Results: The diameter of all formulations was in the range 11.2-11.85mm; thickness was in the range 3.95-4.09 mm. The hardness ranged from 4 to 4.5 kg/cm ^[2]. All formulations passed the USP requirements for friability and uniformity of weight. The buoyancy time of all tablet formulations was less than 5 min and tablet remained in floating condition throughout the study. Conclusion: The optimized formulation was found to be F6 which released 98.4% of drug in 11 h in vitro, while the buoyancy time was 3.5 min

DOI: 10.22271/phyto.2018.v7.isp6.1.18

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