Author(s):

Anil Hooda

Abstract: MELAS is condition in which multiple body system impaired. It mainly occurred in children and at any age. MELAS is characterized by headache, weakness in body parts, pains, and loss of appetite, cognitive impairment and seizures. Several mechanisms such as mitochondrial proliferation, nitric oxide synthase, reactive oxygen species, dysfunction of endothelial, RNA and angiopathy are involved in pathophysiolocal basis of MELAS. Several genes mutation are involved in this complex illness. No specific medication available for management of MELAS. It is progressive consequences to severe neurological disorders and even death of patients. This review paper highlights the clinical signs and symptoms, genetic aspect and pathogenesis mechanism of MELAS.

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