Optimization of antifungal activity and chemical study of Terminalia mantaly extracts

Yayé Yapi Guillaume; Obouayéba Abba Pacôme; Ackah Jacques Alfred Auguste Bognan; Djaman Allico Joseph

Optimization of antifungal activity and chemical study of Terminalia mantaly extracts

Author(s):

Yayé Yapi Guillaume, Obouayéba Abba Pacôme, Ackah Jacques Alfred Auguste Bognan and Djaman Allico Joseph

Abstract:

Context: We are witnessing an increasing number of mycosis due to a weakened immune system, resistance and the limited number of antifungal agents. Hence the need to develop other antifungal agents with pronounced activity.

Methodology: The soxhlet extract obtained from hydroalcoolic extract of Terminalia mantaly bark was chromatographed on Sephadex gel G25. The extracts obtained and a ketoconazole, were tested on the in vitro growth of fungal isolates. A chemical study (phytochemical screening, TLC and HPLC) was carried out.

Results: Of the 19 extracts obtained, the F₈, F₉, F₁₀ and P extracts showed the best activities (MFC = 24.37 µg/mL and 12.18 µg/mL respectively on A. fumigatus and C. albicans, C. neoformans). The chemical study revealed the phenols and quinones that could be responsible for this activity.

Conclusion: This extraction resultd in more pronounced antifungal activity which would be due to phenols and/or quinones.

Pages: 700-705 | 1095 Views 374 Downloads

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Journal of Pharmacognosy and Phytochemistry

How to cite this article:

Yayé Yapi Guillaume, Obouayéba Abba Pacôme, Ackah Jacques Alfred Auguste Bognan and Djaman Allico Joseph. Optimization of antifungal activity and chemical study of Terminalia mantaly extracts. J Pharmacogn Phytochem 2020;9(5):700-705.

Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

Vol. 9, Issue 5 (2020)

Optimization of antifungal activity and chemical study of Terminalia mantaly extracts

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