Armandine Lema, Koudbi Jacob Zongo, Wendkouni Leila Marie Esther Belem-Kabre, Mamadou Sawadogo, Hermann Yempabou Ouoba, Pierre Alexandre Eric Djifaby Sombie, Noufou Ouedraogo and Mindiédiba Jean Bangou

The aim of this study was to perform phytochemical investigations of three medicinal plants oriented against antioxidant and anti-inflammatory activities. The spectrophotometer was used for quantification tests. The antioxidant activity was evaluated by ABTS●+, DPPH● and FRAP method. The acute toxicity (OECD 423) and the anti-edematous activity were performed on NMRI mice. Phytochemical screening allowed the identification of some chemical groups. Ethanolic extracts of Guiera senegalensis showed the best total phenolic contents (97.77±0.30 g EAA/100 g extract) and the best antioxidant activity with ABTS●+ (IC₅₀: 3.86±0.17 μg/mL), DPPH● (IC₅₀: 12.20±0.02 μg/mL) and FRAP (32.80±0.55 mmol EAA/g) methods. The extracts showed an inhibitory effect on 15-lipoxygenase activity (14.67 to 99.49% at 100 µg/mL). The aqueous decoction (68.10%) and the ethanolic macerate (74.21%) of the recipe showed a good percentage of inhibition of edema from the 5th hour at a dose of 400 mg/kg b.w. These results could constitute a solid scientific basis justifying the traditional uses of these plants.

DOI: 10.22271/phyto.2024.v13.i5a.15054

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