MD Abid Hasan, Sefat E Munjerin, Zobaer Al Mahmud and Nazmul Qais

The leaves of Pothos scandens L. have been extracted with methanol for the investigation of hypoglycemic, anthelmintic, and antioxidant activities. The powdered leaves of Pothos scandens L. were extracted with methanol & the concentrated extract was further partitioned with petroleum ether, ethyl acetate, chloroform (CHCl₃)_, and carbon tetra chloride (CCl₄). In the evaluation of hypoglycemic activity, the crude extract, along with petroleum ether, CCl₄, and ethyl acetate fractions, showed a potential reduction in the blood glucose level, with decreases of 51.0%, 32.6%, 37.9%, and 29.4%, respectively. For comparison, glibenclamide, a standard hypoglycemic drug, reduced blood glucose level by 41.7% after 45 minutes of glucose administration. Regarding anthelmintic activity, the crude extract exhibited paralysis at 12.2 minutes (at 25 mg/ml); 5.7minutes (at 50 mg/ml); 2.8 minutes (at 100 mg/ml), and death of earthworms at 18.3 minutes (at 25 mg/ml); 7.7 minutes (at 50 mg/ml); 4 minutes (at 100 mg/ml) while earthworms exposed to 10 mg/mL albendazole survived for 56.8 minutes. These results indicate that the leaf extract has promising anthelmintic properties, potentially comparable to the standard reference drug, albendazole. For antioxidant activity, the crude methanolic extract and its petroleum ether, CCl_4, and CHCl₃ fractions_, exhibited IC₅₀ values of 109.5, 21.28, 49.28, and 39.12 µg/ml respectively. The BHT and ethyl acetate fractions showed comparable results, with IC₅₀ values of 12.92 µg/ml and 12.64 µg/ml, respectively.

DOI: 10.22271/phyto.2025.v14.i1a.15215

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