Adil Usman, Ali Raza Kashif, Muhammad Asadullah, Haleema Bibi and Muhammad Usama Younas

This study investigates the therapeutic potential of Mangifera indica (mango) leaves, focusing on their antioxidant, cytotoxic and thrombolytic properties using different solvent extracts. Quantitative analysis revealed significant concentrations of bioactive compounds: tannins (2.03 mg/100g), alkaloids (3.5 mg/100g) and saponins (5.32 mg/100 g). The concentrated crude extracts recovered from mango leaves showed yields ranging from 6.79-13.76 g/100 g. These CCEs demonstrated prominent amounts of total phenolic and flavonoid content varying from 198-318 GAE (mg/100 g) and 167-291 CE (mg/100g). Hemolytic and thrombolytic assays demonstrated the extracts' low toxicity and effective blood clot reduction capabilities. At concentrations below 500 µg/mL, the extracts exhibited non-toxic effects on human erythrocytes. Given their rich phytochemical profile and bioactivities, this research underscores the promise of Mangifera indica leaves in drug development, nutraceuticals and functional foods. The findings advocate further exploring these extracts in traditional and modern medicine for disease prevention and treatment.

DOI: 10.22271/phyto.2025.v14.i1e.15260

Pages: 373-379  |  320 Views  101 Downloads