Thota Srinivas, Potella Mohammad Sadik, Nadakuditi Prabhavathi, Thota Manasa, Doppalapudi Pradeep, Bhodanapu Saranya, Patan Bilal and B Thangabalan

Obesity is a growing global health concern, increasing the risk of various chronic diseases such as type II diabetes, heart diseases, and hypertension. This review explores the theoretical hypothesis of appetite suppressants as a potential strategy for weight management. Appetite regulation is controlled by complex mechanisms involving hormonal signals, digestion, and body conditions. Many synthetic appetite suppressing drugs have been discontinued due to severe side effects, leading to increased interest in herbal and natural alternatives. This study highlights the role of medical plants such as caralluma fimbriata, green tea, flaxseeds, ginger, almond, aloe vera, pine apple, pear, chia seeds, apples and oats in appetite suppression. These natural suppressants work through various mechanisms, including enzyme inhibition, Fiber-induced satiety, and hormonal modulation. Bioactive compounds such as pregnane glycosides, epigallocatechin gallate, dietary Fiber, and omega-3 fatty acids contributes to their appetite-controlling properties. Additionally, this review discusses the physiological processes of satiations and satiety, focusing on key hormones like cholecystokinin (CCK), glucagon-like peptide-1 (GLP) and peptide YY (PYY), which regulate hunger and fullness. Understanding these mechanisms can help in developing functional food and dietary interventions to control appetite effectively. While herbal remedies offer promising benefits, their safety and efficacy require further clinical validation. A combined approach incorporating multiple natural suppressants along with lifestyle modification such as diet and exercise may be the most effective strategy for long term weight management. This study underscores the need for further research to optimize natural appetite suppressants for combating obesity.

DOI: 10.22271/phyto.2025.v14.i2f.15325

Pages: 496-501  |  139 Views  66 Downloads