Md Tauhidul Islam and Nazmul Qais

The powdered leaves of Licuala peltata were extracted with methanol, and the concentrated extract was then fractionated using petroleum ether, ethyl acetate, chloroform (CHCl₃), and carbon tetrachloride (CCl₄). The crude methanolic extract and its fractions were found to possess antioxidant, cytotoxic, and thrombolytic effects.

In evaluation of antioxidant activity, the methanolic crude extract (IC₅₀ of 19.22 µg/ml) and petroleum ether fraction (IC₅₀ of 9.022 µg/ml) showed significant free radical scavenging activity compared to standard Ascorbic Acid (IC₅₀ of 4.918 µg/ml). Regarding the brine shrimp lethality bioassay, methanolic crude extract (LC₅₀ of 13.03 µg/ml) and its different solvent-soluble fractions like petroleum ether, carbon tetrachloride, chloroform exhibited cytotoxic activities with the LC₅₀ values of 4.452 µg/ml, 15.114 µg/ml, 7.08 µg/ml respectively compared to the Vincristine Sulphate (LC₅₀ of 0.5316 µg/ml). For the thrombolytic activity, the chloroform soluble fraction exhibited the highest clot lysis activity of 12.536% and the petroleum ether soluble fraction showed moderate activity of 10.707%, compared to the standard thrombolytic agent streptokinase which exhibited high activity of 68.180%.

This study demonstrates the medicinal potentials of Licuala peltata to be used as antioxidant and a potential candidate for thrombolytic, cytotoxic agent.

Pages: 196-201  |  654 Views  234 Downloads