Prajwal Kadlag, Gauri Salave, Prajwal Aher and Anil Jadhav

It is recognized that by intrinsic boost to the activity of absorption, distribution, metabolism and excretion i.e. (ADME) properties results into increase in therapeutic effect of the drug. By altering distribution of drug by conjugating toxic drug to antibodies having high affinity towards cancer cell specified antigens in order to increase both therapeutic efficiency of cancer and decreasing to toxicity towards it. By directly altering intrinsic absorption, distribution, metabolism and excretion i.e. (ADME) through modifications of the drug which is limited or precluded by structural requirements for activity Polymeric micelles have recently gained attention as a promising colloidal delivery system for targeting poorly soluble and amphiphilic medications. They are regarded as more stable in comparison to surfactant micelles and can encapsulate significant quantities of hydrophobic substances within their inner core. Several numbers of polymer related therapies are presently in the market and they are undergoing clinical evaluation for the treatment of cancer and other diseases. Many of them are low molecular weight drug molecules or therapeutic proteins which are chemically linked to water-soluble polymers for increasing the drug solubility and drug stability or enable to target tumors.

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