Rohini S Pundge and Arvind S Dhabe

The present research aimed to examine the effectiveness of Berberis aristata DC. hydroethanolic extract in human lung cancer cell lines A549. The cytotoxicity assay and cell viability were investigated using the cytotoxicity assay performed at the Department of Biosciences, Sardar Patel University, Gujarat.

The cytotoxicity of B. aristata DC. crude extract investigated against lung adenocarcinoma cell lines A549 gave an IC₅₀ value of 47.84 ± 0.49 (μg/ml), indicating its effectiveness as a potential anti-cancer agent. Notable changes in the morphology of the selected cell lines were also noted. The MTT assay revealed that the Berberis aristata DC extract demonstrates significant cytotoxicity against A549 cells, suggesting a potential anti-cancer agent.

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