Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 2, Issue 6 (2014)

Investigation of anticonvulsant activity of Vanda roxburghii

Author(s): Dilnawaz Pathan, Shirishkumar Ambavade
Abstract: Purpose: The aim of the study was to investigate anticonvulsant effect of alcoholic extract of roots of Vanda roxburghii on electrically and chemically induced seizures. Methods: The ethanolic extract of the roots of Vanda roxburghii (SVR) was studied for its anticonvulsant effect on maximal electroshock-induced seizures pentylenetetrazole, picrotoxin induced seizures in mice. The latency of tonic convulsions and the number of animals protected from tonic convulsions were observed. Results: It has been observed in the present study that the ethanolic extract of roots of Vanda roxburghii (100 mg/kg) showed significant (P<0.05) increase in latency to clonic convulsions. Vanda roxburghii possess anticonvulsant activity against Pentylenetetrazole (PTZ), Maximal electroshock (M.E.S.) and Picrotoxin (PTX) induced convulsions in mice.
Effect of extract of on Pentylenetetrazole induced convulsions.
Fig.: Effect of extract of on Pentylenetetrazole induced convulsions.
Pages: 95-99  |  1313 Views  12 Downloads
How to cite this article:
Dilnawaz Pathan, Shirishkumar Ambavade. Investigation of anticonvulsant activity of Vanda roxburghii. J Pharmacogn Phytochem 2014;2(6):95-99.
Journal of Pharmacognosy and Phytochemistry