Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 3, Issue 1 (2014)

Phytochemical Characteristics, Antimitotic, Cytotoxic and Antiinflamatory Activities of Coccinia grandis (L.) J. Voigt

Author(s): A.N.M. Alamgir, Minhajur Rahman, Ataur Rahman
Abstract: Coccinia grandis (L.) J. Voigt, grows in the wild all over Bangladesh, is known to exhibit certain therapeutic properties. In the present work, leaf extract of C. grandis was considered for qualitative assessment of its secondary metabolite contents such as alkaloids, flavonoids, glycosides, saponins, sterol and tannins. Antimitotic, cytotoxic and antitumor activities of the ethanolic extract of leafwere also determined. Leaf extract showed strong inhibitory effect on seed germination, seedling’s root growth of wheat and brine shrimp lethality with LC50 at 24.20 μg/ml. Antitumor assay showed inhibition of tumor induction on potato discs due to Agrobacterium tumefaciens by 66% at 1000ppm without any lethal activity against the bacterial agent. Results of anticarcenogenic activities of the leaf extract were discussed in relation to its secondary metabolites content.
Effects of ethanolic extract of C. grandis leaf on crown gall tumor formation at different concentrations.
Fig.: Effects of ethanolic extract of C. grandis leaf on crown gall tumor formation at different concentrations.
Pages: 222-225  |  1138 Views  18 Downloads
How to cite this article:
A.N.M. Alamgir, Minhajur Rahman, Ataur Rahman. Phytochemical Characteristics, Antimitotic, Cytotoxic and Antiinflamatory Activities of Coccinia grandis (L.) J. Voigt. J Pharmacogn Phytochem 2014;3(1):222-225.
Journal of Pharmacognosy and Phytochemistry