Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 3, Issue 3 (2014)

Antimicrobial and cytotoxic activities of extracts from Sterculia quinqueloba (Garcke) K. Schum and Canthium crassum Hiern

Author(s): Elihuruma Wilson, Musa Chacha, Justin Omolo
Abstract: Sterculia quinqueloba (Garcke) K. Schum and Canthium crassum Hiern extracts were evaluated for antimicrobial activity using 96-well-microtitre serial micro-dilution method against Vibrio cholera, Klebsiella oxytoca, Klebsiella pneumonia, Streptococcus pyogenes, Staphylococcus aureus and Candida albicans. All extracts exhibited antimicrobial activity with minimum inhibition concentration range of 0.39 – 12.5 mg/mL. The S. quinqueloba leaf methanolic extract had the highest activity with minimum inhibitory concentration range of 0.78 – 1.56 mg/mL and 0.78 – 1.50 mg/mL against bacterial and fungal species respectively. The lethality test against brine shrimp larvae revealed that S. quinqueloba and C. crassum leaf extracts with LC50 value range of 113.439 – 840.537 µg/mL is non-cytotoxic. The antimicrobial activity and lethality results indicate therapeutic potency of Sterculia quinqueloba and Canthium crassum.
Pages: 125-129  |  1195 Views  5 Downloads
How to cite this article:
Elihuruma Wilson, Musa Chacha, Justin Omolo. Antimicrobial and cytotoxic activities of extracts from Sterculia quinqueloba (Garcke) K. Schum and Canthium crassum Hiern. J Pharmacogn Phytochem 2014;3(3):125-129.
Journal of Pharmacognosy and Phytochemistry