Vol. 3, Issue 5 (2015)
Identification of glucosidases inhibitory potential from Citrullus lanatus seed extract
Author(s): Jayavelu Sathya, Mabel Parimala and Francis Gricilda Shoba
Abstract: The aim of the study was to evaluate the α-amylase and α-glucosidase inhibitory potential of Citrullus lanatus seed methanol extract in regulating postprandial hyperglycemia. In vitro α-amylase and α-glucosidase inhibition assay was performed by standard protocols using the extract at ten different concentrations. The methanolic extract of C. lanatus exhibited the best inhibitory activity against α-glucosidase with IC50 values of 54.44 μg/ml and a mild inhibitory activity against α-amylase with IC50 values of 76.68 μg/ml. Hence, from the present study, we conclude that C. lanatus seed methanol extract is a potent glucosidase inhibitor which can be used in the management of type 2 diabetes.
How to cite this article:
Jayavelu Sathya, Mabel Parimala, Francis Gricilda Shoba. Identification of glucosidases inhibitory potential from Citrullus lanatus seed extract. J Pharmacogn Phytochem 2015;3(5):12-14.