Author(s):

Dhanasree Basipogu, Nizamuddin Basha Syed

Abstract: Background: Medicinal plants are source of a wide variety of natural antioxidants. The dietary antioxidant consumption may be a worthy approach for inhibiting or delaying the oxidation of susceptible cellular substrates and thus is relevant to disease objection in many paradigms. Maytenus emarginata is a locally available plant and it is less known folk medicinal plant. This plant used by the tribes of Nallamala forest of Kurnool district for the inflammation, ulcers, and even for the treatment of gastritis and tonsils. Purpose of this study: In our present study we demonstrated the reducing power, total antioxidant potential, radical scavenging capabilities and α-glycosidase inhibitory property of different crude extracts of Maytenus emarginata leaf. Methodology: In this study The leaf powder was subjected to sequential extraction in a soxhlet apparatus using different solvents such as Hexane, Ethyl acetate, Ethanol and Water. The capability of deactivation of free radicals scavenging activities were evaluated with in vitro bioanalytical methods like •OH, DPPH•, SO2- NO, and then α-glucosidase inhibitory property is also evaluated.rnResults:The extracts of Maytenus emarginata scavenged radicals effectively in varied degree. Similarly, the total reducing power of alcohol extract was found higher in both phospho molybdenum and FRAP methods. In vitro assay of α-glucosidase activity of MEA and MEW showed an IC50 of 173.47 and 286.66 µg/ml respectively, while other two extracts did not show any significant effect. In other hand, total phenolic and total flavonoid contents of extracts were studied, where values of Aqueous extract were found to be higher than that of other extracts. Statistical Analysis: Graph pad prism 5software was used for statistical analysis and to prepare the graphical representation of results. Conclusion: we found that Ethanol and Aqueous extracts of Maytenus emarginata contain significantly effective antioxidant and radical scavenging activities as compared to other extracts. Addition to this Maytenus emarginata has shown a remarkable α-glycosidase inhibition also. Potential implication: Our experimental study provides an evidence for the ethno-botanical claims and reported ethno pharmacological activities that Maytenus emarginata leaves have a significant therapeutic potential.

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