Author(s): Sally Abd El-Monem El-Nawasany, Said Ibrahim Shalaby, Farid Abd El- Rahim Badria, Gamal Mohammad Magraby and Neelima Gupta

Abstract: Herbs such as Fenugreek are known to have a diuretic effect in cirrhotic ascitic patients. The safety, tolerability and possible diuretic efficacy of Fenugreek were investigated. A study was carried out on 50 patients: Group I: Furosemide 40 mg tablet and Spironolactone 100 mg tablet once daily for 7 days, Group II: Fenugreek methanol extract 500 mg capsule twice daily for 7 days. Basal and final body weight, urine volume (24h), mean arterial blood pressure, Na and K in serum and 24h urine were estimated. In Group I, the mean loss of body weight was significantly greater. The mean of urine Na excretion in Group I significantly increased. Mean of serum Na decreased significantly in Group I, insignificantly increased in Group II. Values of K excretion were insignificant. No side effects were detected. This is the first human clinical trial indicating that Fenugreek is safe and tolerable.