Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 6, Issue 5 (2017)

Effect of the hydro-alcoholic leaves extract of Paullinia pinnata (Lin.) on rats skeletal muscle regeneration after contusion injury and phytochemical analysis

Author(s): Bwassiwè Hele, Kossi Metowogo, Aklesso P Mouzou, Kodjo Adi, Judith Ahounou, Christian Cognard, Kwashie Eklu-Gadegbeku, Pierre H Dansou and Kodjo A Aklikokou
Abstract:
The present study aimed to investigate the muscle-protective effect of PPLE against muscle contusion injury. One hundred wistar rats were divided into five groups (n = 20): a control group, an untreated group and 3 treated groups. At day 0, all the animals except control rats were subjected to muscle contusion injury. Control and untreated groups received orally the vehicle while treated groups received the hydro-alcoholic PPLE (100, 200, and 500 mg/kg) once a day, for 14 days. The blood of five animals of each group was collected in order to evaluate the rates of LDH, CK, AST and ALT enzymes. Hydroxyproline content and histopathological analyses were investigated. Phytochemical screening was performed. Only untreated rats showed increased serum concentration and decreased hydroxyproline content. Histopathological analysis showed myotubes formation in the treated groups. Phytochemical analysis revealed the presence of tannins and flavonoids which could have positive effect on the regeneration process.
Pages: 361-367  |  752 Views  18 Downloads
How to cite this article:
Bwassiwè Hele, Kossi Metowogo, Aklesso P Mouzou, Kodjo Adi, Judith Ahounou, Christian Cognard, Kwashie Eklu-Gadegbeku, Pierre H Dansou, Kodjo A Aklikokou. Effect of the hydro-alcoholic leaves extract of Paullinia pinnata (Lin.) on rats skeletal muscle regeneration after contusion injury and phytochemical analysis. J Pharmacogn Phytochem 2017;6(5):361-367.
Journal of Pharmacognosy and Phytochemistry