Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 6, Issue 6 (2017)

Hepatoprotective and antioxidant activity of methanolic leaves extract of Cassia arereh in CCl4-induced rat liver damage

Author(s): Abbas AY, Muhammad FI, Dallatu MK, Abubakar AL and Sahabi SM
Abstract:
Liver disease is still a worldwide problem. Cassia arereh is one out of many medicinal plants in Northern Nigeria used for the management of liver diseases. The study was designed to evaluate the hepatoprotective effects of Cassia arereh against CCl4 - induced liver damage in rats. Standard analytical methods were employed in all the parameters assessed. Administration of methanolic leaves extract of C. arereh at doses of 50, 100, 150, 200 mg/kg body weight significantly(P<0.05) reduced the elevated serum liver marker enzymes and lipid peroxidation index (Malondialdehyde) and also increased the levels of total protein, albumin and endogenous antioxidants when compared to CCl4 – induced not treated group. The hepatoprotective effect observed might be due to its rich phytochemical constituents.
Pages: 1346-1353  |  455 Views  10 Downloads
How to cite this article:
Abbas AY, Muhammad FI, Dallatu MK, Abubakar AL, Sahabi SM. Hepatoprotective and antioxidant activity of methanolic leaves extract of Cassia arereh in CCl4-induced rat liver damage. J Pharmacogn Phytochem 2017;6(6):1346-1353.
Journal of Pharmacognosy and Phytochemistry