Vol. 7, Issue 1 (2018)
Role of monoamine Oxidase A (MAOA) in drug addiction
Author(s): Aarti Sharma, Anit Kumar, Vineet Kaswan, Naveen Kaushik and Amit Kaushik
Abstract: Monoamine oxidase A (MAOA), an enzyme that affects dopamine, norepinephrine, and serotonin. Monoamine oxidase (MAO) is expressed in brain and with regional variation. It helps in metabolizing neurotransmitter molecules and dietary amines. It is is a candidate gene for studying anti-social and other behavioural disorders like Brunner syndrome in humans. Monoamine oxidase A degrades different types of monoamines and has been associated with greater degrees of aggression and impulsivity in the general population. MAOA promoter polymorphism confers increased susceptibility to anti-social behavior rather than alcohol dependence per se in alcohol-dependent males and quantitative behavioural traits. The monoamine oxidase-A have been hypothesized to have a relationship with alcoholism and personality traits. These discrepancies imply that the MAOA-uVNTR functional polymorphism might not play a crucial role in behavioral or physiological variability in humans. MAOA had a vital role in regulating personality traits by altering serotonin levels which regulated behaviour and can be act as a biomarker to predict the risk to being a drug addicted. Drug addiction is a very poweful demon that can put your life in danger before a person has live his life. Goverment should take actions for this cause will destroy families and will lead to a life full of sorrow.
How to cite this article:
Aarti Sharma, Anit Kumar, Vineet Kaswan, Naveen Kaushik, Amit Kaushik. Role of monoamine Oxidase A (MAOA) in drug addiction. J Pharmacogn Phytochem 2018;7(1):727-729.