Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 7, Issue 2 (2018)

Modulatory effects of gallic acid on sodium fluoride induced nephrotoxicity in the wistar rats

Author(s): Ola-Davies OE and Azeez OI
Abstract: Background: Exposure to environmental chemical contaminants such as Sodium Fluoride appears to be a regular part of life. It is therefore, necessary to limit their effects through the use of natural products.
Objective: To evaluate the modulatory/protective effect of gallic acid on the nephrotoxic effect of sodium fluoride in rats.
Materials & Methods: The study included four groups of twenty-four adult male Wistar, weighing 220 ± 5.6 g. The rats were divided into four groups, A – D consisting of six rats per group. Group A, was given distill water, while group B, received 300 ppm of NaF only, Group C, 300 ppm NaF and 60 mg/kg of gallic acid, group D, 300 ppm NaF and 120 mg/kg of gallic acid per os for 7 days. Samples were collected for haematology; biochemistry and histology.
Results: The PCV and RBC values were higher in the rats exposed to NaF and 120 mg/kg of gallic acid while the MCV was lower in NaF alone. Significant signs of neutropenia and kidney damage and inflammation were also observed which were ameliorated by gallic acid.
Conclusion: The study further established that NaF induces kidney damage by increasing inflammation in the soft tissue, which was attenuated by gallic acid.
Pages: 1561-1570  |  353 Views  7 Downloads
How to cite this article:
Ola-Davies OE, Azeez OI. Modulatory effects of gallic acid on sodium fluoride induced nephrotoxicity in the wistar rats. J Pharmacogn Phytochem 2018;7(2):1561-1570.
Journal of Pharmacognosy and Phytochemistry