Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 10, Issue 1 (2021)

Inhibitory activities of ethanol extracts from Boesenbergia rotunda, Zingiber purpureum, and Alpinia galanga on in vitro agonists induced human platelet aggregation

Author(s): Serm Surapinit, Ratchaniporn Kongsui, Napatr Sriraksa, Sitthisak Thongrong and Suttira Sedlak
Abstract: The rhizomes of Boesenbergia rotunda, Zingiber purpureum, and Alpinia galangal are well-known Thai medicinal plants has been used as spice and folk medicine due to its numerous functional and nutritional properties. The present study, the anti-platelet aggregation activities of the ethanol extracts from the rhizomes of rhizomes of B. rotunda, Z. purpureum, and A. galangal were evaluated using 96-well plate platelet aggregation assay. The ethanol extracts from B. rotunda, Z. purpureum, A. galanga (IC50 0.064 ± 0.039, 0.019±0.721, and 0.113±0.031 µg/mL) were more active than the ibuprofen (IC50 0.439 ± 0.064 µg/mL) in ADP-induced platelet aggregation (P<0.05). The inhibitory activity of extract from Z. purpureum (IC50 0.024±0.08 µg/mL) was comparably active to the ibuprofen (IC50 0.036±0.006 µg/mL) in the AA induced platelet aggregation; however, the extracts from B. rotunda and A. galangal (IC50 0.054±0.031 and 0.068±0.026 µg/mL) were less potent than ibuprofen (P<0.05).The ethanol extracts from B. rotunda and Z. purpureum (IC50 0.025±0.008 and 0.012±0.015 µg/mL) were more potent than ibuprofen (IC50 0.056±0.023 µg/mL) in collagen-induced platelet aggregation (P<0.05). The extracts from Z. purpureum and A. galanga (IC50 225±0.094 and 190±0.075 µg/mL) possessed inhibitory activities on thrombin-induced platelet aggregation. The ethanol extracts from the rhizomes of rhizomes of B. rotunda, Z. purpureum, and A. galangal were inactive in the platelet aggregation assay using U-46619 and TRAP-6 as agonists.
Pages: 27-31  |  83 Views  13 Downloads
How to cite this article:
Serm Surapinit, Ratchaniporn Kongsui, Napatr Sriraksa, Sitthisak Thongrong, Suttira Sedlak. Inhibitory activities of ethanol extracts from Boesenbergia rotunda, Zingiber purpureum, and Alpinia galanga on in vitro agonists induced human platelet aggregation. J Pharmacogn Phytochem 2021;10(1):27-31.
Journal of Pharmacognosy and Phytochemistry